| First Name | Last Name | Teams Played For | Age | Career WHIP | Career ERA | Career Strikeouts | Average Strikeouts per Year | Career Saves | Average Saves per Year | Number of Seasons | All-Star Seasons | Number of All-Star Seasons | Cy Young | Number of Cy Youngs | Other Accolades |
| Mat | Latos | PIT, CHW, STL, HOU* | 40 | 1.01 | 3.57 | 2136 | 126 | 112 | 7 | 17 | 2014, 2015, 2016, 2017, 2018 | 5 | None | 0 | None |
| Earl | Hardy | MIN, CHW*, LAA, TKY | 40 | 1.03 | 3.25 | 2530 | 149 | 34 | 2 | 17 | 2012, 2013, 2014, 2015, 2016, 2017, 2018 | 7 | 2012, 2019 | 2 | None |
| Clayton | Kershaw | CHW, SEA, KC, TKY | 40 | 1.1 | 3.54 | 2018 | 135 | 61 | 4 | 15 | 2016, 2017 | 2 | 2017 | 1 | None |
| Fernando | Tristan | BOS, KC, BKY, WAS | 40 | 1.13 | 3.83 | 1016 | 92 | 92 | 8 | 11 | 2014, 2016 | 2 | None | 0 | None |
| Stephen | Strasburg | CIN, LAD, WAS, TOR, HOU* | 39 | 1.04 | 3.29 | 2991 | 176 | 36 | 2 | 17 | 2012, 2014, 2015, 2016, 2018 | 5 | None | 0 | None |
| Chris J. | Sale | TOR, MIN, NYY, WAS, CHW* | 39 | 0.92 | 2.52 | 1331 | 78 | 190 | 11 | 17 | 2013, 2015, 2016, 2017 | 4 | None | 0 | None |
| Carlton | Haas | DET, LAD, TOR, CHC, PHI, SP* | 39 | 1.03 | 2.98 | 626 | 48 | 123 | 9 | 13 | 2016, 2018 | 2 | None | 1 | 2018 Reliever of the Year |
| Manny | Banuelos | KC/SHG*, BAL, CHW, SEO, ATL | 38 | 1.08 | 3.79 | 2632 | 155 | 70 | 4 | 17 | 2018 | 1 | None | 0 | None |
| Chris | Chesnut | COL, PHI* | 38 | 1.11 | 3.98 | 2024 | 127 | 78 | 5 | 16 | None | 0 | None | 0 | None |
| Jameson | Taillon | SD/SP, ARI/OSK* | 38 | 1.17 | 4.09 | 2116 | 124 | 59 | 3 | 17 | 2013 | 1 | 2021 | 1 | None |
| Yu | Darvish | TEX, NYY, CIN/SEO, STL, BAL, NYM* | 38 | 0.98 | 3.32 | 1781 | 127 | 102 | 7 | 14 | 2015, 2017, 2018 | 3 | 2018 | 1 | None |
| Drew | Rivers | MIN, BOS, MIA, TKY, TOR* | 38 | 1.05 | 3.26 | 1229 | 88 | 101 | 7 | 14 | 2015 | 1 | None | 0 | None |
| Cedric | Joyner | PIT, MIA, CHW, ARI/OSK, SEO, SHG* | 37 | 1.13 | 3.92 | 2866 | 179 | 0 | 0 | 16 | 2018 | 1 | 2020 | 1 | None |
| Roberto | Rivera | COL, PHI | 37 | 1.08 | 3.81 | 1821 | 121 | 42 | 3 | 15 | 2018 | 1 | 2022 | 1 | None |
| Lucas | Sims | MIL, BAL | 37 | 1.03 | 3.57 | 777 | 65 | 220 | 18 | 12 | 2015, 2017 | 2 | None | 0 | None |
